Author: adminmautiste

Both groups were similar in terms of gender, age, weight, body mass index, ASA physical status and type of surgery performed. In terms of comorbidities, both groups were similar, except for the presence of chronic obstructive pulmonary disease. There was 100% compliance to the designated PaCO₂ intraoperative targets. The median (IQR) PaCO₂ in the TMH group and TN groups were 51.5 mm Hg (46.9–60.9) and 34.8 mm Hg (32.8–38.1), respectively (p<0.001). With regards to surgical characteristics, the duration of surgery was longer in the TMH group, with a median (IQR) duration of 219 min (124–304) versus 144 min (108–218) in the TN group, although this was not significant at the 5% level (p=0.121). PaO₂ was similar between the two groups: 156.8 mm Hg (146.3–217.2) in the TMH group and 142.5 mm Hg (122.5–199.1) in the TN group (p=0.380). Oxygen saturation was similar: 98.5% in the TMH group (98.1–99.0) and 98.5% in the TN group (97.9–99.0) (p=0.834). Both groups also had similar mean arterial pressure (MAP) intraoperatively (p=0.307), similar total Hb (130.5 vs 122.2 g/L; p=0.132) and received similar total doses of intravenous morphine equivalent opioid, mg in the TMH group (–) and mg in the TN group ( - ) (p=0.22). In terms of intraoperative positioning of patients, one patient from each group was positioned in steep reverse Trendelenburg with minimal tilt. All other patients were positioned in the supine position with a neutral head position.

Interestingly, the incidence of postoperative delirium after surgery was lower in the TMH group, while LOS remained similar between the groups. Patients who suffered from postoperative delirium were all in the TN group, but they were also older (median (IQR) age=72 (59.5–77)) and had higher ASA scores (ASA scores of 3, 2, 1, 4 and 4). Their baseline medical comorbidities and duration of surgery (median (IQR) duration of surgery=171 min (83.5–254.5)) were similar to other study participants.