Cox proportional potential risks habits were used so you’re able to guess RRs and you can 95% CIs

28 Jun Cox proportional potential risks habits were used so you’re able to guess RRs and you can 95% CIs

RRs (95% CI) of total, ischemic, and you can hemorrhagic strokes from the quintiles off joint diet score to own magnesium, potassium, and you can calcium supplements intakes inside 86,149 feamales in the newest NHS We and 94,715 feamales in the NHS II step one

I current the newest meta-analyses out-of prospective studies away from losing weight magnesium ( 21), potassium ( 22), dating sites for Sikh people and calcium ( 23) consumption and threat of heart attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

RRs (95% CI) out of total, ischemic, and hemorrhagic shots by quintiles out-of joint diet plan scores getting magnesium, potassium, and you can calcium intakes during the 86,149 women in brand new NHS I and you will 94,715 women in this new NHS II step 1

I upgraded the latest meta-analyses regarding prospective degree regarding weight-loss magnesium ( 21), potassium ( 22), and you can calcium ( 23) consumption and danger of coronary attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.

I looked at overall and dietary intakes of any nutrient and you will exposure away from coronary attack to choose any possible nonlinear relationship that with limited cubic splines; however, zero extreme deviation from linearity is actually observed. At the same time, i looked the potential impression amendment because of the decades, blood circulation pressure, otherwise diabetes on the relatives between total intake of all 3 vitamins and danger of total coronary attack. Zero tall perception amendment is actually observed from the such things.

Prior meta-analyses incorporated comes from early in the day analyses throughout the NHS ( 10); these types of results was in fact replaced of the contributes to the modern research. On top of that, the new literary works try searched, and you will present possible knowledge ( 8, 24) have been included in these upgraded meta-analyses. No anywhere between-training heterogeneity was seen the of your own step 3 minerals. This new shared RR away from full coronary arrest is 0.87 (95% CI: 0.83, 0.92) having a 100-mg/d increase away from magnesium intake, 0.91 (95% CI: 0.88, 0.94) to own a good 1000-mg/d boost regarding potassium intake, and you will 0.98 (95% CI: 0.94, step 1.02) to possess a 3 hundred-mg/d raise out of calcium consumption.